What happens a decade after you get the HPV vaccine?

2022-07-04 0 By

HPV vaccine, can be said to be the first human can effectively prevent cancer vaccine.It can not only effectively prevent cervical cancer caused by high-risk HPV infection, but also prevent anal cancer, penile cancer and other cancers caused by similar causes.This means that both men and women can benefit from the HPV vaccine (although most countries in the world, including China, are still “ladies first”).With the spread of the HPV vaccine, many people are asking two questions: Is the HPV vaccine worth getting?How good is it?This year, 15 years have passed since the first human HPV vaccine was released in 2006.The scientists actually found a large number of people who were vaccinated during the 15-year period, studied them, and came up with something worth looking at.In this post, we take a closer look at three of the world’s most recent and authoritative studies.(If you want to save time and get straight to the conclusion, read the text in bold.And don’t forget to click “watching” at the end.)01 Get HPV vaccine, it is very useful to prevent cervical cancer!Almost all cervical cancers (99.7 percent) are linked to HPV infection, which can be effectively prevented by vaccination.So how effective is the HPV vaccine in preventing HPV in the real world?In October 2021, the New England Journal of Medicine (NEJM), one of the world’s leading medical journals, published a study by Swedish scientists.The study involved more than 1.6 million women in Sweden who were followed for more than a decade, a long time span and a large sample size, making it a “landmark study.”Researchers followed 1.673 million Swedish women between the ages of 10 and 30 for 11 years from 2006 to 2017, screening and assessing them for cervical cancer until they reached age 31.If you look at the chart below, you can see that getting the HPV vaccine can significantly reduce the risk of cervical cancer, and the earlier you get it, the better.To be more specific: More than half a million of the 1.67 million women were vaccinated against HPV during the 11 years they were followed.Cervical cancer was diagnosed in 19 of the vaccinated population, with a cumulative incidence of 47 cases per 100 000 women, and in 538 of the unvaccinated population, with a cumulative incidence of 94 cases per 100 000 women.Overall, the HPV vaccine reduced the risk of cervical cancer by 63 percent, after adjusting for age, place of residence, education, family background and medical history.If vaccinated before age 17, the incidence dropped by as much as 88 percent.There’s no need to wait for the “expensive” vaccine, it’s important to get it early!In this study, almost all the Women in Sweden received the tetravalent HPV vaccine (to protect against HPV6, HPV11, HPV16, and HPV18).Another British study sheds light on this question.The UK launched the bivalent HPV vaccination programme in 2008, offering routine vaccinations for girls aged 12 to 13 and supplementary vaccinations for girls aged 14 to 18.In November 2021, the Lancet, a leading international medical journal, published the work of British researchers, which is the largest and longest real-world data on cervical cancer vaccines to date.Effect of the HPV vaccination programme on the incidence of Cervical cancer and grade 3 cervical intraepithelial neoplasia in the UK: an observational study based on registry dataThe Lancet team assessed diagnostic data for cervical cancer and precervical lesions in women aged 20 to 64 living in England between 2006 and 2019.The basic bivalent vaccine was 34 percent effective in preventing cervical cancer and 39 percent effective in preventing severe cervical intraepithelial neoplasia (CIN3) when given at ages 16 to 18.These figures were as high as 87 percent and 97 percent, respectively, when given at 12 to 13 years of age.But even the nine-valent HPV vaccine, given after age 30, is still effective, but not nearly as effective as the bivalent HPV vaccine given at a younger age.The bottom line: for THE HPV vaccine, getting it early is more important than getting it second best.In fact, the World Health Organization (WHO) made it clear as early as 2017 that there is no public health difference in immunogenicity, efficacy and efficacy of the bivalent, quadrivalent and nine-valent vaccines in the prevention of type 16 and 18 (high-risk) HPV-associated cervical cancer, and that all three vaccines prevent the majority of related cancers.This is also very instructive for our practical action: if your family has a daughter over 9 years old, you can let her get the bivalent and quadvalent vaccine first, really do not have to wait for the age of 16 after the nine-valent vaccine.After all, it’s the early benefits of early vaccination rather than “probably better” protection in the future, isn’t it?Since it is necessary to take the HPV vaccine early, how long can the protection of the HPV vaccine last?Would it be early and die early?A Finnish study published in the Lancet Infection addresses this question.The study followed up for 12 years and found that women who received the bivalent HPV vaccine could still detect HPV vaccine-induced antibody titers at 12 years.Sustainability of neutralizing antibodies induced by bivalent or tetravalent HPV vaccine and their Relevance to efficacy: a combined follow-up analysis of data from two randomized, double-blind, multicenter, Phase 3 Trials.The Lancet Infectious Disease (HPV) vaccine has only been on The market for 15 years, and we don’t yet know how protective it is over The longer term.But at least for now, protection is satisfactory and there is no need for booster shots.But here’s the caveat: having the HPV vaccine doesn’t mean you don’t have to worry about cervical cancer anymore.Recommendations for cervical cancer screening: (1) Cytological screening every 3 years for sexually active women aged 21-29 years;(2) Women aged 30 to 65: cytology and COMBINED HPV and DNA testing every 5 years is recommended if conditions are available; cytology and combined HPV and DNA testing every 3 years is recommended if conditions are insufficient;(3) Women over 65 years of age: if the previous multiple screening results are negative, choose whether to be screened based on individual differences or doctors’ advice.You may also want to ask: these are foreign cases, our country’s own?At present, China’s domestic HPV vaccine (currently only 2-valent HPV vaccine) has also shown good safety and protection results in phase III clinical trials.The trial, which began in November 2012, involved more than 7,000 female volunteers who were randomly assigned to receive one dose of the vaccine at 0, 1, and 6 months, respectively, in the vaccine group (vaccinated with the domestic bivalent HPV vaccine) or the control group (vaccinated with the hepatitis E vaccine as a control).After 42 months of follow-up, the efficacy of the home-made bivalent HPV vaccine against precancerous lesions was 100.0% (0/3306 for vaccine group and 10/3296 for control group).The effective rate for preventing persistent infection of HPV16/18 was 97.8% (1/3240 in vaccine group and 45/3246 in control group).In other words, after 17 years of research and development, our researchers have brought a highly effective and safe HPV vaccine to Women in China.This is good news for the popularization of HPV vaccination in China!Universal vaccination really eliminates cervical cancer.Many regions in China, such as Guangdong Province and Chengdu in Sichuan province, have started to offer free HPV vaccination to girls of appropriate age.I believe that more cities and regions will join in the future.Wuxi, Jiangsu province and Lianyungang, Jiangsu Province, will launch the HPV vaccine free vaccination program in December 2021, providing two doses of domestic bivalent HPV vaccine for girls in the second grade of junior high school.Guangdong: Starting in 2022, girls under 14 who are enrolled in the first grade of junior middle school and have not been vaccinated against HPV will be eligible for free vaccination.Chengdu, Sichuan: Female students aged 13 to 14 will be given a subsidy of 600 yuan per person for vaccination, and they can choose between domestic/imported 2-valent and 4-valent HPV vaccines.Parents (guardians) shall bear the difference of vaccine fee and vaccination service fee (2 YUAN/dose) after subsidy.Ordos city, Inner Mongolia: Women aged 13 to 18 receive three doses of HPV vaccine for free (the vaccination period is 0 months, 1 month and 6 months), and the public only needs to pay the vaccination service fee.Jinan, Shandong province: Girls in seventh grade who are under 14 years old (before 15 years old) and have no history of HPV vaccination can be vaccinated free of charge.In Wenchuan county and Maerkang City of Sichuan Province, free vaccinations will be offered to girls aged 9 to 14 in the next three years.Just in 2020, WHO released its Global Strategy to Accelerate the Elimination of Cervical Cancer, which set 90% HPV vaccination coverage, 70% screening coverage, and 90% access to precancerous lesions and cervical cancer treatment by 2030.By “HPV vaccination coverage”, we mean that 90 per cent of girls in all countries by the age of 15 will have been vaccinated against HPV by 2030.In other words, if you are vaccinated against HPV, you are not only protecting yourself, but also contributing to a better future of eliminating cervical cancer.If you know a girl of appropriate age, you can also forward this article to her or her family, so that effective vaccines can help more girls.Let us look forward to one day in the future, cervical cancer can really be eradicated by human beings, and wish you, who have been vaccinated against HPV, can witness the arrival of this day!Guest author: Shili Zhuang and master of Neuroscience reviewer, Hokkaido University, Japan:Lu Xuexin, Assistant researcher, Institute of Viral Disease Prevention and Control, China CDC, Immunology doctor liu Haifang, Deputy chief physician, Department of Obstetrics and Gynecology, Huashan Hospital affiliated to Fudan University-END- I knew you were “watching.”